Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate
CAS: 94-09-7
Molecular Formula: C9H11NO2
Ethyl 4-aminobenzoate - Names and Identifiers
| Name | Ethyl 4-aminobenzoate |
| Synonyms | NSC 4688 Benzocaine Benzocione H-4-Abz-OEt Benzocaine, USP, EP Ethyl 4-aminobenzoate Ethyl p-aminobenzoate 4-(Ethoxycarbonyl)phenylaMine 4-(ethoxycarbonyl)aniliniumato (p-(Ethoxycarbonyl)phenylaMine 4-Aminobenzoic acid ethyl ester Benzocaine(See B197952 for Labelled) 4-Aminobenzoic Acid Ethyl EsterBenzocaine |
| CAS | 94-09-7 |
| EINECS | 202-303-5 |
| InChI | InChI=1/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3/p+1 |
| InChIKey | BLFLLBZGZJTVJG-UHFFFAOYSA-N |
Ethyl 4-aminobenzoate - Physico-chemical Properties
| Molecular Formula | C9H11NO2 |
| Molar Mass | 165.19 |
| Density | 1.17 |
| Melting Point | 88-90°C |
| Boling Point | 172 °C (12.7517 mmHg) |
| Flash Point | 172°C/13mm |
| Water Solubility | Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water |
| Solubility | alcohol: soluble1 gm in 5 ml |
| Vapor Presure | 0.000589mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | White |
| Merck | 14,1086 |
| BRN | 638434 |
| pKa | 2.5(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5600 (estimate) |
| Physical and Chemical Properties | Density 1.17 melting point 89-92°C boiling point 172°C (17 torr) |
| Use | For cosmetics UV absorption, local anesthetics, for wounds, ulcers and hemorrhoids pain |
Ethyl 4-aminobenzoate - Risk and Safety
| Risk Codes | R43 - May cause sensitization by skin contact R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24 - Avoid contact with skin. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | 3077 |
| WGK Germany | 2 |
| RTECS | DG2450000 |
| TSCA | Yes |
| HS Code | 29224995 |
| Hazard Class | 9 |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 3042mg/kg |
Ethyl 4-aminobenzoate - Standard
Authoritative Data Verified Data
This product is ethyl p-aminobenzoate. The content of C9H11N02 shall not be less than 99.0% calculated as dried product.
Last Update：2024-01-02 23:10:35
Ethyl 4-aminobenzoate - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless; Light color gradient yellow.
- This product is soluble in ethanol, chloroform or ether, slightly soluble in fatty oil, and slightly soluble in water.
melting point
The melting point of this product (General 0612) is 88~91°C.
Last Update：2022-01-01 13:33:57
Ethyl 4-aminobenzoate - Differential diagnosis
Authoritative Data Verified Data
- take about 0.1g of this product, add 5ml of sodium hydroxide test solution, and boil, that is, ethanol is generated; Add iodine test solution and heat, that is, yellow precipitate is generated, and the odor of iodoform occurs.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 237).
- This product shows the identification reaction of aromatic first amines (General rule 0301).
Last Update：2022-01-01 13:33:58
Ethyl 4-aminobenzoate - Exam
Authoritative Data Verified Data
acidity
take this product l. Add 10ml of neutral ethanol (neutral to phenolphthalein indicator solution) to dissolve, add 2 drops of phenolphthalein indicator solution and 0.1 ml of sodium hydroxide titration solution (0.10 mol/L), which should be light red.
clarity and color of solution
take this product l.Og, add ethanol 20ml after dissolution, the solution should be clear and colorless.
chloride
take 0.2g of this product, add 5ml of ethanol to dissolve, add 3 drops of dilute nitric acid and 3 drops of silver nitrate test solution, and the turbidity shall not occur immediately.
Related substances
take this product, add anhydrous ethanol to dissolve and dilute to make a solution containing 10mg per lml as a test solution; Take an appropriate amount of precision, quantitative dilution with absolute ethanol was made to contain 0.01mg, 0.025mg, 0.05mg and 0.1mg solution, as a control solution. According to the thin layer chromatography (General 0502) test, absorb the above five solutions of 20 u1, respectively, on the same silica gel GF2S4 thin layer plate, with anhydrous ethanol-chloroform (0.75:99.25) as the developing solvent, after deployment, dry and view under UV light (254nm). If there are impurity spots in the test solution (if the impurity spots are observed at the origin, the impurity spots should be counted), compared with the main spots of the control solution, the total amount of impurities shall not exceed 1.0%.
loss on drying
take this product, put the phosphorus pentoxide dryer to dry to constant weight, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 13:33:58
Ethyl 4-aminobenzoate - Content determination
Authoritative Data Verified Data
take this product about 0.35g, precision weighing, according to the permanent stop titration method (General 0701), with sodium nitrite titration solution (0.lmolL) titration. Each lm of sodium nitrite titration solution (0.1 mol/L) corresponds to 16.52mg of C9H11N02.
Last Update：2022-01-01 13:33:59
Ethyl 4-aminobenzoate - Category
Authoritative Data Verified Data
local anesthetic.
Last Update：2022-01-01 13:33:59
Ethyl 4-aminobenzoate - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:33:59
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